The human neural cell adhesion molecule L1 functions as a costimulatory molecule in T cell activation
نویسندگان
چکیده
منابع مشابه
Impact of L1 Cell Adhesion Molecule on Macrophage Activation
INTRODUCTION Nowadays, per research study, around 5.6 million people around the United States suffer from paralysis [1]. There are many reasons that contribute to paralysis: stroke, spinal cord injuries, multiple sclerosis and so on. Patients who suffer from paralysis lose partial or fully sensory function and motor intention. Although paralysis is not life-threatening for most of the patients,...
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On neural cells, the cell adhesion molecule L1 is generally found coexpressed with N-CAM. The two molecules have been suggested, but not directly shown, to affect each other's function. To investigate the possible functional relationship between the two molecules, we have characterized the adhesive interactions between the purified molecules and between cultured cells expressing them. Latex bea...
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Mutations in the L1 neural cell adhesion molecule, a transmembrane glycoprotein, cause a spectrum of congenital neurological syndromes, ranging from hydrocephalus to mental retardation. Many of these mutations are single amino acid changes that are distributed throughout the various domains of the protein. Defective herpes simplex virus vectors were used to express L1 protein with the clinical ...
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The neural cell adhesion molecule L1 is involved in nervous system development and promotes regeneration in animal models of acute and chronic injury of the adult nervous system. To translate these conducive functions into therapeutic approaches, a 22-mer peptide that encompasses a minimal and functional L1 sequence of the third fibronectin type III domain of murine L1 was identified and conjug...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2000
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200003)30:3<938::aid-immu938>3.3.co;2-h